Lupus erythematosus profundus (lupus panniculitis) induced by interferon-β in a patient with multiple sclerosis
نویسندگان
چکیده
We report a patient with multiple sclerosis (MS) who developed subcutaneous nodules in the face, shoulders and extremities while being treated with interferon (IFN)-β-1b. These nodules fluctuated in parallel with myelopathy, and were diagnosed as lupus erythematosus profundus (LEP) based on histopathological findings. The patient showed no relapse of either neurological symptoms or subcutaneous nodules after cessation of IFN-β-1b. This agent can cause induration and necrosis in the sites of injection but also systemic skin lesions such as LEP ascribable to its immunomodulatory effects.
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1. Nelson WE, Vaughan III, VC, McKay, Jr., RJ and Behrman RE, editors. Textbook of pediatrics, Philadelphia, 1979, W B Saunders Company. 2. Rudolph AM, Barnett HL, and Einhorn AH, editors: Pediatrics, ed 16, New York, 1977, Appleton-CenturyCrofts. 3. Irgang S: Lupus erythematosus profundus. Report of an example with clinical resemblance to Darier-Roussy sarcoid, Arch Dermatol 42:97, 1940. 4. Fo...
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